The growing demand for sites with access to targeted patient populations—alongside increasingly complex protocols and the operational burden of proliferating technologies—requires new ways of working together to modernize clinical trials for the future. SCOPE’s 2nd Annual Site Engagement & Operations stream brings together sponsors, sites, and other critical stakeholders including CROs, technology providers, and patient-facing partners to explore how stronger collaboration, aligned incentives, and shared innovation can lead to more efficient, inclusive, and sustainable trial delivery. With a strong focus on education, alignment, and collaboration, this stream equips both sites and sponsors with the tools and perspectives needed to drive more efficient, inclusive, and sustainable trial operations.