Patient-centric protocol development and improving DEI are the latest hot-button issues impacting clinical trials today. Incorporating patient voice into clinical trial design and conduct leads to better recruitment, retention, satisfaction, and to increased likelihood of trial success. And at the same time, there is an imperative to improve diversity and inclusion of representative patient populations. CHI’s Patient-Centric Trial Design & Protocol Optimization evaluates new protocol design strategies, methods to incorporate participant voice, and collaborative approaches to reduce site and patient burden. The Developing & Executing DE&I Programs conference will provide the latest on the FDA’s diversity plan requirements and submission process, analyze barriers to clinical trial diversity and efforts to overcome them and offer actionable insights to improve diversity, equity, and inclusion in clinical trials.