Analytics-driven global site selection, an optimized protocol development and feasibility assessment process, and effective site management, and the ability to improve study start up in multi-center and decentralized trials are critical to improving clinical trial timelines and outcomes. Too often companies fail to learn from past mistakes and take the same approach to protocol development, trial planning, and execution. SCOPE’s Protocol Development, Feasibility, and Global Site Selection track will cover the topics one should consider when planning and implementing a data-driven and patient-centered trial. The Study Start-up in Multi-Center and Decentralized Trials track highlights strategies for accelerating multi-center and decentralized trials in a post-COVID world.