The abundance of data generated during routine health care is growing in significance and should be used for clinical and observational research. Patient electronic records, registries, data from pharmacy and social media, and wearable sensors have been increasingly used as eSources. This process requires strategizing, implementing novel data technologies, as well as close collaboration between pharmaceutical companies and organizations that possess the data. CHI’s 14th Annual Accessing and Generating RWD conference is designed to facilitate knowledge exchange around all aspects of real-time, real-world data generation, its quality, and applications. The stream includes two unique parts, each of which features its own set of topics and speakers.